Anti-SARS-CoV-2 (2019-nCoV) Nucleocapsid antibody

DATASHEET

Host:Rabbit

Target Protein:SARS-CoV-2 (2019-nCoV) Nucleocapsid

IR:Immunogen Range:

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:43740575

Swiss Prot:P0DTC9

Source:KLH conjugated synthetic peptide derived from SARS-CoV-2 Nucleocapsid Protein: 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Background:Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.

Size:100ul

Concentration:1mg/ml

Applications:

Cross Reactive Species:SARS-CoV-2.

For research use only. Not intended for diagnostic or therapeutic use.